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Their effectiveness in the long run requires their combination with the following: Healthy eating habits Regular physical activity Ongoing medical supervision The weight loss from GLP-1 drugs must be slow and sustainable rather than quick and erratic

These agonists have shown impressive anti-obesity effects in preclinical models and are currently being evaluated in phase 2 clinical trials (118)

Unlike some psychiatric drug candidates where the mechanism of action is poorly understood, the GLP-1 pathway in reward circuitry has been extensively mapped

Four studies have examined risks of major congenital malformations, all-cause maternal mortality and fetal cardiac or kidney anomalies, and none have found an increased risk after GLP-1 RA exposure compared with various reference groups

Some patients find that injecting their GLP-1 medication before bedtime reduces daytime nausea, though this approach should be discussed with your prescriber first

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