Compared with other CVOTs involving GLP-1RA, participants in the AMPLITUDE-O trial had the longest duration of diabetes (15 years), lowest mean eGFR (72 ml/min/1.73 m 2 ) with a higher percentage (32%) of people with renal disease (eGFR 2560 mL/min), highest glycosilated hemoglobin (8.9%), and highest percentage of insulin use (62%) or sodiumglucose transporter-2 inhibitors (SGLT-2i) (15%) at baseline, thus identifying a more fragile population
Valid only for option purchased
A full work-up (BMP, A1C, lipid panel, TSH) usually costs $80-150 cash through Quest or LabCorp
At the maximum 15mg dose, average weight loss reached 22.5%
Although Mounjaro for type 2 diabetes offers effective management of the condition, for weight loss, Klinic provides alternatives like Zepbound, Wegovy, and Foundayo
I would also argue that estrogen hormone therapy, progesterone, testosterone, when indicated, is going to have a synergistic effect with these GLP ones