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2.2 Negative Regulation of Ferroptosis by p53 In addition to its ferroptosis-promoting effects, p53 represses ferroptosis by inducing cyclin-dependent kinase inhibitor (CDKN1A, encoding p21), Parkinson disease 2 (PARK2) and iPLA2, or by inhibiting dipeptidyl peptidase-4 (DPP4) (Kang et al., 2019) (Figure 2)

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Nahurira R, Ren L, Song J, Jia Y, Wang J, Fan S, Wang H, Yan Y (2017) Degradation of di(2-ethylhexyl) phthalate by a novel Gordonia alkanivorans strain YC-RL2