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Gigliotti, MS, RDN, CDCES, CSOWM
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This review examines the link between diabetes and neurodegenerative diseases, explores the effects of antidiabetic agents on neurodegeneration, provides a concise overview of the GLP-1 pathway, and discusses both preclinical and clinical trial outcomes of GLP-1RAs for neurodegenerative diseases, including their effects on cognition in AD and PD
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In 2004, researchers conducted a meta-analysis of 61 randomized controlled trials evaluating GLP-1 RAs, sodium-glucose co-transporter-2 inhibitors (SGLT2i), dipeptidyl peptidase 4 inhibitors (DPP-4i) and didnt find an increased risk of diabetic retinopathy events with GLP-1 RAs or any of the other classes of antihyperglycemic medications
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