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& Pervan, M

It is important that the two phases of estrogen metabolism act in sync

aaopm.com 9Healthline (April 2026)

Individual Risk Factors for Depression During GLP-1 Treatment Patients with a personal or family history of depression, bipolar disorder, or other mood disorders appear to carry higher risk for mood changes during GLP-1 therapy

It is not a substitute for a GLP-1 medication

NICE guidance emphasises the importance of appropriate patient selection, monitoring, and education about potential adverse effects before initiating treatment with these medications