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Increased Risk of Adverse Side Effects Both semaglutide and tirzepatide share common gastrointestinal side effects, including nausea, vomiting, diarrhea, and constipation

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Your doctor will typically recommend either: 2.5mg tirzepatide (the lowest dose) for 4 weeks, then increase 5mg tirzepatide if you tolerated semaglutide well Patients already on GLP-1 medications can often start tirzepatide at 5mg safely, though the exact starting dose should follow your provider's recommendation based on how well you tolerated semaglutide