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In parallel, generative models such as RoseTTAFold and RFdiffusion [51, 52] have enabled de novo design of antibody scaffolds and binding interfaces

Such a trial would likely take several years and cost tens of millions of dollars, but the potential payoff, a new treatment option for a condition that affects over a billion people worldwide, justifies the investment

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This cohort comprised 45 participants in the 3 mg group, 92 participants in the 7 mg group, and 32 participants in the 14 mg group, respectively ( Figure 1 )

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