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Importantly, liraglutide has been found to modulate cytokine production in i NKT cells without impairing their cytotoxic function [77]

doi: 10.1530/JOE-11-0094

in 2022, Martins & colleagues showed that women with overweight who experienced an average weight loss of 16% had a metabolic adaptation of approximately ~50kcal/day. Meaning, while metabolic adaptation does occur, its not likely the primary culprit of a stalled diet

Doctors can prescribe pramlintide off label for weight loss, but it is not officially approved for this use

Discussion Summary of findings In the present study, we found that the risk of MOF was slightly lower, albeit not significantly, in those treated with GLP-1 RA compared to those treated with DPP-4is as add-on therapies to metformin

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