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Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

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463,464 It reduces inflammation and improves symptoms primarily by suppressing the effects of TNF- and is typically used in patients who do not respond to or are intolerant to conventional treatments such as 5-aminosalicylic acid