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Inhibition of glutamate and increase in GABA differentially affect soluble A binding to pre-existing plaques in APP-PS1 and hypertension models Previously, a method for microinjection of soluble A was developed to assess A binding ability in the brain

The neuropathology consists of atrophy of the cerebral hemispheres, medial temporal lobe, thalamus, mammillary body, and brainstem, with ventricular dilation and fenestrated cavum septum pellucidum

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