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, Steinmeier J., Stapelfeldt K., and Dringen R

Glucosuria also enhances gluconeogenesis and ketogenesis, part of an SGLT2 inhibitor induced shift to a fasting state. Ketogenesis is hypothesized to be a direct mediator of cardioprotection with SGLT2 inhibition since ketone bodies are an efficient energy source with the potential to improve myocardial energy dynamics and exert direct anti-inflammatory effects [1820]

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Consider using second-generation antihistamines, as they have not been reported to cause false-positive UDS results

This finding suggests that DPP4 inhibitors, owing to their GLP-1-enhancing actions, may have a direct beneficial effect on cardiomyocyte function

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