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More critically, copper can directly bind to the cysteine residues of GPX4, triggering its autophagic degradation and consequent loss of activity, which impairs the cell's ability to repair lipid peroxidation [65]

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vehicle, two-way ANOVA, for interaction factor, P =0.8122

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The most common side effects are similar to those seen with injectable semaglutide, including mild nausea and gastrointestinal discomfort

To identify differentially expressed genes (DEGs), we used the Limma R package 40 , which enables robust differential expression analysis in microarray experiments