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In animal experiments, sunitinib, a VEGFR-2 inhibitor, completely inhibited pilocarpine-induced angiogenesis and seizures (72)

Modified protocols may be necessary for those with compromised kidney function

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increased 5OXP was associated with increased biosynthesis whilst OPA production indicated the depletion of the sulfur-containing amino acids essential for GSH biosynthesis.35 Whilst poor nutritional status may predispose some subjects to toxicity via a reduced ability to produce GSH for NAPQI-detoxication other metabolic factors may also come into play

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