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Cant, C

Gydesen, S

Caradonna, L., Amati, L., Magrone, T., Pellegrino, N., Jirillo, E., & Caccavo, D

This is a significant advantage over medications that require daily injections, greatly improving patient convenience and adherence

Gut microbiota can convert tryptophan into metabolites such as 5-hydroxytryptamine (5-HT, serotonin) and kynurenine

Clinical trials and meta-analyses indicate that berberine significantly reduces total cholesterol, LDL, and triglycerides (while raising HDL) in patients with dyslipidemia, an effect partly due to upregulation of LDL receptor expression in the liver and modulation of AMPK-dependent lipid metabolism