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Collect baseline and follow-up (e.g., 1, 3, 6, 12 months) vaginal symptom PROMs, vaginal pH, microbiome sequencing, HbA1c, hydration markers, sex hormones (oestradiol/estrone/SHBG), and weight trajectory

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Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in mice

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resveratrol effectively reduces bone loss due to its potent antioxidant capabilities (Zhao et al., 2015)