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The cellular metabolic alteration of increased L-2-HG levels contributes to the regulation of histone and DNA methylation levels by inhibiting epigenetic modification enzymes that use -ketoacid as a cofactor

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But sometimes the bigger risk is that alcohol or drugs are making it hard to take medicine on time or make safer choices

Clinicians need to balance continued metabolic advantages against changed physiology that may increase anesthetic and operative hazards

Maintain adequate fluid intake