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Chronic magnesium deficiency may have severe consequences leading to cellular dysfunction and death, including a depletion of glutathione, as magnesium is essential to its production

BarreaLMegnaMCacciapuotiSFrias-ToralEFabbrociniGSavastanoSet al

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In this study, we examined that decreased mtDNA content preceded the development of NIDDM{Non-insulin dependent diabetes mellitus) and correlated with various insulin resistance parameters.In this study, we demonstrated that the amount of mtDNA decreased in peripheral blood leukocyte of patients with NIDDM