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The biological underpinnings of menopausal depression involve fluctuating and declining estrogen levels, which modulate serotonergic and dopaminergic neurotransmission

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The article points to people with elevated fasting glucose, significant insulin resistance and preserved pancreatic beta-cell function, the profile where metformin's insulin-sensitizing action has something to work on

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JACC Basic Transl Sci 4:575591 Tochiya M, Makino H, Tamanaha T, Matsuo M, Hishida A, Koezuka R, Ohata Y, Tomita T, Son C, Miyamoto Y, Yasuda S, Hosoda K (2020) Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type 2 diabetes and heart diseases: A pilot study

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