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Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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I had almost no pain or stiffness and I even started exercising regularly

Signs that insulin may be needed include persistently elevated blood sugar despite maximum GLP-1 doses, declining endogenous insulin production, and treatment plateaus that suggest the incretin-based approach has reached its limits

Results: A total of 172 patients were recruited from six institutions, including 86 patients with CSPH and 86 patients without CSPH (61 patients were liver fibrosis F0-F1 without HVPG)

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