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There was no statistical significance in the development of ION between cohorts, 1-year hazard ratio of 0.872 (95% CI: 0.6271.212), 3-year HR of 1.002 (95% CI: 0.7921.268), and 5-year HR of 0.978 (95% CI: 0.7891.211)

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So dry mouth is not just annoying, it is a dental-health issue worth managing properly: keep hydration up, use fluoride toothpaste (a dentist may suggest a higher-strength one), keep up cleanings, and mention the dry mouth to your dentist so they can watch for early decay

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We could end up doing ourselves a lot of damage and we need to treat this drug with the respect that it deserves. Mellor adds that some private providers of the drug may struggle to support people in the longer term

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