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A randomised clinical trial published in JAMA Psychiatry (Hendershot et al., April 2025, the first controlled human trial of a GLP-1 for alcohol use disorder), found that semaglutide significantly reduced alcohol craving and the amount consumed during a laboratory drinking procedure, with medium-to-large effect sizes
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This paper presents, at best, weak evidence of an association between semaglutide and suicidality, said Ian Douglas, a professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine
