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Avoid frost-free freezers with defrost cycles if possible, as the temperature fluctuations are not ideal

Studies treating mild to moderate B12 deficiency in older people have failed to provide cognitive benefits: A clinical trial from the Netherlands measured the cognitive response to B12 supplements in people 70 years old with mild B12 deficiency and MMA levels 320 nmol/l (average: ~450 nmol/l)

Frequently Asked Questions About B12 Injections How soon will I feel a difference with B12 Injections

Translational Andrology and Urology, 5 (6), 834-843

Whilst uncomfortable and sometimes socially distressing, burping typically reflects the medication's intended action rather than a serious adverse reaction

In practice, that packaging is most of the story