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Nature (2022) 612, 16

GCLC activation assay using -lipoic acid To evaluate the effect of enhancing glutathione pathway activity on tissue regeneration, an experimental regimen using -lipoic acid, a known activator of GCLC (the rate-limiting enzyme of glutathione synthesis), was administered to a subset of animals

Potential Side Effects and What to Watch For While glutathione is a natural substance, taking it in supplement form can lead to side effects in some individuals