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During the study period, three participants discontinued treatment: two due to gastrointestinal adverse effects (nausea and vomiting) and one due to PsO exacerbation [154]

The results showed GLP-1 drugs had little to no effect on the risk of cancers such as breast, thyroid, pancreatic or kidney cancer

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Although the authors postulate that these actions were mediated through potentiation of direct GLP-1 actions on hepatocytes, it seems unlikely that hepatocytes express the canonical GLP-1R (216)

T.BermdezM.Segura-ValdezM