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Earlier biguanides such as phenformin and buformin showed greater potency but were withdrawn from the market due to a high incidence of lactic acidosis ( Pharmacokinetically, metformin is absorbed primarily in the small intestine, with a bioavailability of approximately 50%60% under fasting conditions (Table 1), depending on the formulation (immediate- vs

This potentially generated hypertension, insulin resistance, obesity, hypertriglyceridemia and metabolic syndrome 61

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