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60 M) but with significantly lower affinity for oxidized glutathione

doi: 10.1111/and.v51.10 102 MajzoubAAgarwalA

In conclusion, we show that chronic in vivo GSH deficiency, despite inducing CYP2E1 and hepatic oxidative stress, triggers adaptive mechanisms that protect the liver against ethanol-induced toxicity

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Rice DC, Kim HW, Putnam JB, Smythe WR, Swisher SG , Vaporciyan AA, Walsh GL, Lee JJ, Sabichi A, Lippman SM, Roth JA

By inhibiting COX2, acetaminophen blocks prostaglandin G2 production, reducing pain and fever but with less of an anti-inflammatory effect