These findings support the further investigation of once-weekly dosing of tirzepatide in Japanese individuals with T2D
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In the SURPASS clinical trial program for type 2 diabetes, diarrhea occurred in approximately 12-16% of patients receiving tirzepatide across various doses (5 mg, 10 mg, and 15 mg weekly), compared to lower rates in comparator groups
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[53] In two of these (NCT03954834 and NCT04039503), participants were randomly assigned to receive either tirzepatide or placebo injection weekly