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and placebo (470 mg cellulose)

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In general, a urine flow rate of less than 1 L per day increases the risk of stone formation (Curhan 2012), and guidelines for people with a history of kidney stones include the recommendation to maintain their urine output above 2 L per day (Antonelli 2015)

As a result, methylation may be disrupted, leading to a range of health issues, including mood disorders associated with undermethylation and copper overload

Thus, the mechanism responsible for the pericentral damage pattern of OTA still remains to be elucidated