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Structural studies have demonstrated that these agents differ in their capacity to induce receptor internalization, duration of signaling, and tissue specificity factors that influence both metabolic and neurobehavioral outcomes [27,29]

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HDACi can improve the efficacy of chemotherapeutic agents by altering the epigenetic state of tumor cells, thereby promoting cell cycle arrest and inducing apoptosis (84)

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Austin (TX): Schultz Publishing LLC, 2013.48

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