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Lactylation of lysine residues at H3K9, H3K18, H4K8, and H4K12 can modulate the expression of genes involved in glucose metabolism, thereby accelerating the fibrotic process in the liver (124)

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The transcription factor ATF4 in turn activates stress-responsive genes such as Tribbles homolog 3 (Trib3) and solute carrier family 7 member 11 (Slc7A11) to mediate protective effects of the integrative stress response 16

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