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In addition to GLP-1R agonists, orally administrated DPP4-inhibitors, e.g., sitagliptin and saxagliptin , which are known to potentiate the effect of endogenous GLP-1 by inhibiting its degradation, have also been clinically studied as protective agents against retinopathy (Isik et al., 2017), and Parkinsons disease (Svenningsson et al., 2016) in T2D patients, although DPP4-inhibitors cannot cross the blood-brain barrier (Mousa and Ayoub, 2019)

Fibrillogenic amylin evokes islet -cell apoptosis through linked activation of a caspase cascade and JNK1

They reduce the intensity and frequency of cravings, but cravings may still occur in certain situations

10.1039/c7mt00083a [DOI] [PubMed] [Google Scholar] Barrett C

& Eslick, G