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10.3168/jds.2017-13201 60

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Concomitantly, ROS can oxidatively activate Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) via methionine oxidation (e.g., Met281/282 oxidation), producing sustained kinase activity that phosphorylates mitochondrial Ca 2+ handling proteins such as the mitochondrial calcium uniporter (MCU) or its regulatory subunits

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