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L-carnitine's potential to modulate impaired glucose metabolism in MASLD has attracted increasing investigative attention

2.4 CHAC1-mediated regulation of stem cell fate and development via NOTCH1 signaling Given the central role of glutathione in maintaining redox balance, its levels are a key determinant of stem cell fate

Direct interaction between N -acetylcysteine and cytotoxic electrophile an overlooked in vitro mechanism of protection

the oral option Foundayo is already FDA-approved and available for patients who want to avoid injections entirely Who Faces the Greatest Benefit From Extended-Dosing Options Based on current research on GLP-1 adherence challenges: Patients with needle phobia or injection anxiety who have delayed starting GLP-1 therapy Patients who report forgetting their weekly injection or injecting on the wrong day People with irregular weekly schedules including shift workers, frequent travelers, and caregivers for whom a consistent weekly schedule is difficult to maintain Patients who stopped weekly GLP-1 therapy specifically because of the injection burden An oral pill eliminates injection entirely and is already available through Foundayo for eligible patients

Acknowledgements We thank Prof Wangsen Cao for their critical review and thoughtful discussion of the manuscript

Diabetic Retinopathy Complications: For individuals with type 2 diabetes and pre-existing diabetic retinopathy, there may be a risk of complications