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Singlet oxygen ( 1 O 2 ) Singlet Oxygen is an atypical ROS which is generated not by electron transfer to O 2 , but rather by the reaction of chlorophyll (Chl) triplet state in the antenna system with O 2

In contrast to peripheral capillaries, special structures such as pericytes, basal lamina, and astrocyte end feet cover the periphery of the vessels around capillaries in the CNS

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Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

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