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In the CNS, p-aminophenol is conjugated to arachidonic acid by fatty acid amide hydrolase (FAAH) to yield AM404

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Consistent with the data in mice, the activation of circulating neutrophils as an indicator for the activation status of hepatic neutrophils showed no neutrophil activation during the injury phase but substantial activation (ROS, phagocytosis) selectively during the recovery phase [98]