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Progr Cardiovasc Dis

Zinc plays an important role in ammonia metabolism and its detoxification in the liver.24,25 Other factors that contribute to the development of HE are lactate and excess manganese.26 7 HE is characterized by neurologic, neuropsychiatric, and musculoskeletal alterations, whose clinical presentation is variable and heterogeneous

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In the STEP 1 trial, the 2.4 mg dose led to an average weight loss of 14.9% over 68 weeks

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They work as coenzymes in many enzymatic processes that help cells produce energy [5]