To date, incretin-based approaches for obesity management appear as the most promising and rapidly developing (Supplementary Table 1), with innovations such as once-weekly (OW) injectable triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), cagrilintide (long-acting amylin analogue)/semaglutide 2.4 mg (CagriSema) combination, GCGR/GLP-1R dual agonists, high-dose oral semaglutide, and oral non-peptide GLP-1 receptor agonist orforglipron, with relevant implications in terms of patients compliance and environmental sustainability
It can take 35 weeks to reach a maintenance dose of liraglutide, while for semaglutide, it takes much longer : up to nine weeks for Rybelsus, up to 13 weeks for Ozempic, and up to 21 weeks for Wegovy
Dosing errors, contamination risk, storage problems, sterility issues, and inaccurate labeling can all create serious health concerns
Preclinical studies have shown that semaglutide decreased nicotine and alcohol consumption
If gastric emptying is delayed, a pill meant to be absorbed quickly may take longer to reach effective levels, which could matter for time-sensitive medications
For someone using liraglutide long-term, that adds up
