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In the clinical conditions presented in the review, increased intestinal permeability has been demonstrated, but the central question of whether the barrier dysfunction is a primary event in the pathophysiology or a consequence of the disease is still not resolved in most diseases

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Unlike alpha-hydroxy acids, which work on the surface, salicylic acid gets into the pore lining and clears the sebum and debris driving the breakout

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Phase 3 CagriSema (Garvey et al., NEJM 2025