comparing the efficacy of liraglutide 1.2 mg/day vs
[PubMed: 9887164] 4
Genetic testing for GLP-1R and GIPR variants may help contextualize individual response potential, though genetics inform rather than determine clinical outcomes
Liu X, George GC, Tsimberidou AM, Naing A, Wheler JJ, Kopetz S , Fu S, Piha-Paul SA, Eng C, Falchook GS, Janku F, Garrett CR, Karp DD, Kurzrock R, Zinner R, Raghav KPS, Subbiah V, Meric-Bernstam F, Hong DS, Overman MJ
Doubling daily KLOW intake (5 mg instead of 2.5 mg) produces stronger receptor downregulation without proportional metabolic benefit and may trigger transient side effects elevated heart rate, jitteriness, or sleep disruption if the double dose occurred in the evening
Brain Behav Immun 26(6):97987 Fuertig R et al (2016) LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain