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Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management and chronic weight management

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The GPX4 inhibitor ML-162 is included as a positive control.Synonyms: Glutathione Peroxidase 4, PhGPx, Phospholipid Hydroperoxide Glutathione Peroxidase

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It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.2