Wolski, L
Semaglutide and tirzepatide have broadly similar and generally reassuring safety profiles

You should speak to your GP if: You are currently taking any prescription weight loss medication (such as semaglutide, liraglutide, tirzepatide, naltrexone/bupropion, or orlistat) and are planning to try for a baby You have been trying to conceive for 12 months without success (or 6 months if you are over 35), or sooner if you have known risk factors such as irregular or absent periods, suspected tubal disease, severe endometriosis, or a history of pelvic surgery or sexually transmitted infection You have a BMI over 30 and are concerned about how this may affect your fertility or pregnancy You have a condition such as PCOS, hypothyroidism, or type 2 diabetes that may interact with both weight and fertility You have taken weight loss medication and have recently discovered you are pregnant You are using anti-obesity medicines and are not using reliable contraception Your GP can review your current medications, advise on an appropriate washout period before conception, and refer you to specialist services if needed

The amylin signaling pathway is distinct from and complementary to GLP-1 receptor signaling, as amylin primarily influences hedonic appetite pathways (reward-driven eating) while GLP-1 primarily affects homeostatic appetite regulation
Eating slowly, chewing thoroughly, and avoiding lying down within 23 hours after meals can improve digestive efficiency
Scott's Apart Science-Backed GLP-1 Therapy for Sustainable Results Struggling to lose weight despite dieting and exercise