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Cartilage Repair Potential (Animal Data) Evidence quality: Low (one rabbit study) In a collagenase-induced knee osteoarthritis model in rabbits, intra-articular AOD-9604 injections enhanced cartilage regeneration

In terms of efficacy, time to onset, reliability of effect, and duration of effect sufficient to last until onset of regularly scheduled medication are important features for an on-demand therapy [11, 12]

Allow 3-5 days between stopping one route and starting another to assess baseline symptoms

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Implement an organization system that tracks inventory and minimizes searching through refrigerator contents

( Comment: Some commenters expressed concern that CMS underestimated the amount of time and burden it will take hospitals to collect, organize, properly format, calculate, update and report the median payer-specific negotiated charges by MS-DRG