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Over three decades ago, John Bienenstock proposed the concept of a common mucosal immune system, suggesting that the mucosal immune system itself is an organ where mucosal immune cells distributed throughout the body can interact across different mucosal tissues and organs 55

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doi: 10.3389/fmed.2022.812653 64 YuHLinXCenJChengHSeifertO

In this case, IRS1/2 may act as protein scaffolds to lock PI3K in an active conformation

These findings hold promise for the development of therapies aimed at alleviating the burden of stress and anxiety disorders, offering a beacon of hope for depressed patients