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To prevent these toxins from being reabsorbed into the bloodstream (enterohepatic recirculation), patients must take oral binders

Researchers select between these based on the research question sustained elevation research favors DAC, while pulsatile-pattern research favors without-DAC

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They combined this targeting sequence with a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes when internalized by cells

The animals develop seizures, and the authors suggested that the extracellular brain glutamate concentration had become increased, perhaps due to excessive release of glutamate and/or decreased extracellular clearance