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MOTS-C works by activating the AMP-activated protein kinase (AMPK) pathway, a central energy-sensing mechanism that promotes glucose uptake, fatty acid oxidation, and insulin sensitivity

However, after 24 h, the ATP production in HEB cells gradually decreased under the influence of metformin and simvastatin, showing little difference from the control group

Functional studies reveal that A39-mediated glutathione homeostasis and A37-mediated mitochondrial iron uptake operate jointly to support mitochondrial OXPHOS

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Moreover, it has been shown earlier that selenium-containing copolymers can increase in vitro production of IL-2 [42]