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Grading and treatment guidelines: Various guidelines have been developed by professional organizations, such as the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN), to grade the severity of irAEs and provide recommendations for their management

NSAIDs can cause the premature closure of the ductus arteriosus in the fetus, leading to serious complications

But, on the other hand, studies reveal that serotonin contribute to non-alcoholic fatty liver diseases (NAFLD) in rodent models through its degradation products, the reactive oxygen species 20

Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy

Pertwee, 2008

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