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The medication works centrally in the brain's appetite centers while simultaneously affecting peripheral metabolic processes throughout the digestive and endocrine systems

Insulin resistance and PCOS are closely connected, as people with PCOS often have the condition

Glutamic acid decarboxylase (GAD) enzyme converts glutamate to GABA, which is then released from the presynaptic GABAergic neuron and acts on the post-synaptic neuron

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Cinnamon, as a nutraceutical or adjunct therapy, could be strategically combined with existing treatments for metabolic diseases to enhance outcomes

In summary, we believe that Sema may exert cardioprotective effects by activating GLP-1R expressed by P cells, triggering the release of acetylcholine, and regulating ventricular function by activating M muscarinic receptors