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In dark skin tones, the greater concentration of melanin in the skin means hyperpigmentation is more common and takes longer to fade

ClinicalTrials.gov, Identifier: NCT03057613 ( Post-operative Radiation With Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck - Full Text View - ClinicalTrials.gov

AOD 9604 contains a disulfide bridge (from its modified tyrosine terminus), which is sensitive to reducing agents such as ascorbic acid (vitamin C)

The gap between what works and what's marketed comes down to three things: bioavailability, timing, and the specific form of glutathione administered

In addition, most studies show no quantitative increase in melanocytes