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All-trans retinoic acid (ATRA), a stereoisomeric form of retinoic acid, has been shown to inhibit POMC transactivation and ACTH secretion in murine corticotroph tumor AtT20 cells via inhibition of AP-1 and Nur transcriptional activities (32)
Similarly, GLP-1RAs were also demonstrated to exert an inhibitory effect on the growth of breast and cervical cancer, implying the potential application of GLP-1RAs for the treatment of these cancer (10)
The pulsatile release appears important for optimal metabolic effects and reduced side effects
What the Evidence Says Current research supports GHK-Cus ability to drive tissue repair and reduce inflammation, though its use for systemic anti-aging in humans remains experimental, without large-scale clinical trials to date
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