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The Continuum Concept, one of the most fundamental principles of physiology, biology, and disease, explains the status of an individual from optimal health to a hidden imbalance, progressing to severe dysfunction, ultimately leading to disease (41)

As the antibiotics begin to kill off the excess bacteria in the small intestine, the bacterial cells release toxins, such as lipopolysaccharides (LPS)

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Furthermore, Nrf2/HO-1 interacts with the NF-KB and JAK-STAT pathways in various contexts: Nrf2/HO-1 can reduce NF-KB phosphorylation and thereby dampen inflammation, whereas proinflammatory cytokines such as TNF- and IL-6, released following NF-KB activation, upregulate HO-1 in a feedback loop (125, 129)

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Infant's Growth and Nutrition : These medications could potentially affect the infant's growth or nutrient absorption if transferred through breast milk